β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to the CD274 gene promoter region to induce PD-L1 expression, in which AKT activation plays an important role. β-Catenin de...

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Publicado en:J Exp Med
Autores principales: Du, Linyong, Lee, Jong-Ho, Jiang, Hongfei, Wang, Chengde, Wang, Silu, Zheng, Zhihong, Shao, Fei, Xu, Daqian, Xia, Yan, Li, Jing, Zheng, Yanhua, Qian, Xu, Li, Xinjian, Kim, Hyung-Ryong, Xing, Dongming, Liu, Pengyuan, Lu, Zhimin, Lyu, Jianxin
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596815/
https://ncbi.nlm.nih.gov/pubmed/32860047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191115
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