GTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

BACKGROUND: Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged exposure to hyperoxia compromises the clearance of invading pathogens by impairin...

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Detaylı Bibliyografya
Yayımlandı:Mol Med
Asıl Yazarlar: Sitapara, Ravikumar A., Gauthier, Alex G., Patel, Vivek S., Lin, Mosi, Zur, Michelle, Ashby, Charles R., Mantell, Lin L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596622/
https://ncbi.nlm.nih.gov/pubmed/33126860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00224-9
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