Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines

With the advent of highly sensitive technologies such as tandem mass spectrometry and next-generation sequencing, recombinant antibodies are now routinely analyzed for the presence of low-level sequence variants including amino acid misincorporations. During mAb cell culture process development, we...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Boddapati, Shanta, Gilmore, Jason, Boone, Kyle, Bushey, John, Ross, Jonathan, Gfeller, Brian, McFee, William, Rao, Romesh, Corrigan, Greg, Chen, Aaron, Clarke, Howard, Valliere-Douglass, John, Bhargava, Swapnil
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595273/
https://ncbi.nlm.nih.gov/pubmed/33119652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241250
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