Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

BACKGROUND: Schizophrenia is a complex disorder in which the causal relations between risk genes and observed clinical symptoms are not well understood and the explanatory gap is too wide to be clarified without considering an intermediary level. Thus, we aimed to test the hypothesis of a pathway fr...

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Veröffentlicht in:Schizophr Res
Hauptverfasser: Montagnese, Marcella, Knolle, Franziska, Haarsma, Joost, Griffin, Juliet D., Richards, Alex, Vertes, Petra E., Kiddle, Beatrix, Fletcher, Paul C., Jones, Peter B., Owen, Michael J., Fonagy, Peter, Bullmore, Edward T., Dolan, Raymond J., Moutoussis, Michael, Goodyer, Ian M., Murray, Graham K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science Publisher B. V 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594641/
https://ncbi.nlm.nih.gov/pubmed/32389614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.schres.2020.04.022
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