In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors

BACKGROUND: Imagining ways to prevent or treat glioblastoma (GBM) has been hindered by a lack of understanding of its pathogenesis. Although overexpression of platelet derived growth factor with two A-chains (PDGF-AA) may be an early event, critical details of the core biology of GBM are lacking. Fo...

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Publicado en:Neuro Oncol
Autores principales: Bohm, Alexandra K, DePetro, Jessica, Binding, Carmen E, Gerber, Amanda, Chahley, Nicholas, Berger, N Dan, Ware, Mathaeus, Thomas, Kaitlin, Senapathi, U, Bukhari, Shazreh, Chen, Cindy, Chahley, Erin, Grisdale, Cameron, Lawn, Sam, Yu, Yaping, Wong, Raymond, Shen, Yaoqing, Omairi, Hiba, Mirzaei, Reza, Alshatti, Nourah, Pedersen, Haley, Yong, Wee, Weiss, Samuel, Chan, Jennifer, Cimino, P J, Kelly, John, Jones, Steve, Holland, Eric, Blough, Michael, Cairncross, Gregory
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594559/
https://ncbi.nlm.nih.gov/pubmed/32296841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa093
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