IBL-202 is synergistic with venetoclax in CLL under in vitro conditions that mimic the tumor microenvironment

The B-cell receptor signaling pathway and dysregulation of the Bcl-2 family of proteins play crucial roles in the pathogenesis of chronic lymphocytic leukemia (CLL). Despite significant advances in the treatment of the disease, relapse and drug resistance are not uncommon. In the current study, we i...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Shen, Yandong, Crassini, Kyle, Fatima, Narjis, O’Dwyer, Michael, O’Neill, Michael, Christopherson, Richard I., Mulligan, Stephen P., Best, O. Giles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594376/
https://ncbi.nlm.nih.gov/pubmed/33085757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001369
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