IBL-202 is synergistic with venetoclax in CLL under in vitro conditions that mimic the tumor microenvironment

The B-cell receptor signaling pathway and dysregulation of the Bcl-2 family of proteins play crucial roles in the pathogenesis of chronic lymphocytic leukemia (CLL). Despite significant advances in the treatment of the disease, relapse and drug resistance are not uncommon. In the current study, we i...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Shen, Yandong, Crassini, Kyle, Fatima, Narjis, O’Dwyer, Michael, O’Neill, Michael, Christopherson, Richard I., Mulligan, Stephen P., Best, O. Giles
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594376/
https://ncbi.nlm.nih.gov/pubmed/33085757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001369
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