IBL-202 is synergistic with venetoclax in CLL under in vitro conditions that mimic the tumor microenvironment

The B-cell receptor signaling pathway and dysregulation of the Bcl-2 family of proteins play crucial roles in the pathogenesis of chronic lymphocytic leukemia (CLL). Despite significant advances in the treatment of the disease, relapse and drug resistance are not uncommon. In the current study, we i...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Shen, Yandong, Crassini, Kyle, Fatima, Narjis, O’Dwyer, Michael, O’Neill, Michael, Christopherson, Richard I., Mulligan, Stephen P., Best, O. Giles
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594376/
https://ncbi.nlm.nih.gov/pubmed/33085757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001369
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