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Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy

[Image: see text] A highly stereoselective, one-pot, multicomponent method has been developed to synthesize pyrrolizidine- and N-methyl pyrrolidine-substituted spirooxindole derivatives. The [3 + 2] cycloaddition reaction involves the reaction between the dipole azomethine ylides, generated in situ...

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Détails bibliographiques
Publié dans:ACS Omega
Auteurs principaux: Ghosh, Rajat, Vitor, Jorge B., Mendes, Eduarda, Paulo, Alexandra, Acharya, Pratap Chandra
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594148/
https://ncbi.nlm.nih.gov/pubmed/33134696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c03675
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