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Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli

Stringent response mediated by modified guanosine nucleotides is conserved across bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT proteins synthesize the modified nucleotides ppGpp and pppGpp, together referred to as (p)ppGpp. SpoT is also the primary (p)p...

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Veröffentlicht in:Front Microbiol
Hauptverfasser: Sanyal, Rajeshree, Vimala, Allada, Harinarayanan, Rajendran
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593582/
https://ncbi.nlm.nih.gov/pubmed/33178149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.562804
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