Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease

To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new series of 1,2,3-triazole-chromenone derivatives were designed and synthesized based on the multi target-directed ligands approach. The in vitro biological activities included acetylcholinesterase (AChE) and...

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Publicado en:BMC Chem
Autores principales: Karimi Askarani, Hajar, Iraji, Aida, Rastegari, Arezoo, Abbas Bukhari, Syed Nasir, Firuzi, Omidreza, Akbarzadeh, Tahmineh, Saeedi, Mina
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592376/
https://ncbi.nlm.nih.gov/pubmed/33134975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-020-00715-0
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