Evidence of Clinically Meaningful Drug–Drug Interaction With Concomitant Use of Colchicine and Clarithromycin

INTRODUCTION: Colchicine is currently approved for the treatment of gout and familial Mediterranean fever, among other conditions. Clarithromycin, a strong inhibitor of CYP3A4 and P-glycoprotein, dramatically increases colchicine’s half-life, augmenting the risk of a life-threatening adverse reactio...

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Publicado en:Drug Saf
Main Authors: Zapata, Lorenzo Villa, Hansten, Philip D., Horn, John R., Boyce, Richard D., Gephart, Sheila, Subbian, Vignesh, Romero, Andrew, Malone, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592308/
https://ncbi.nlm.nih.gov/pubmed/32274687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-020-00930-7
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