Disruption of Adaptive Immunity Enhances Disease in SARS-CoV-2-Infected Syrian Hamsters

Animal models recapitulating human COVID-19 disease, especially severe disease, are urgently needed to understand pathogenesis and to evaluate candidate vaccines and therapeutics. Here, we develop novel severe-disease animal models for COVID-19 involving disruption of adaptive immunity in Syrian ham...

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發表在:J Virol
Main Authors: Brocato, Rebecca L., Principe, Lucia M., Kim, Robert K., Zeng, Xiankun, Williams, Janice A., Liu, Yanan, Li, Rong, Smith, Jeffrey M., Golden, Joseph W., Gangemi, Dave, Youssef, Sawsan, Wang, Zhongde, Glanville, Jacob, Hooper, Jay W.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Pathogenesis and Immunity
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592214/
https://ncbi.nlm.nih.gov/pubmed/32900822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01683-20
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