Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain

Influenza remains a global health risk and challenge. Currently, neuraminidase (NA) inhibitors are extensively used to treat influenza, but their efficacy is compromised by the emergence of drug-resistant variants. Neutralizing antibodies targeting influenza A virus surface glycoproteins are critica...

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Bibliographic Details
Published in:J Virol
Main Authors: Gao, Rongyuan, Sreenivasan, Chithra C., Sheng, Zizhang, Hause, Ben M., Zhou, Bin, Wentworth, David E., Clement, Travis, Rausch, Dana, Brunick, Colin, Christopher-Hennings, Jane, Wu, Hua, Bausch, Christoph L., Sullivan, Eddie J., Hoppe, Adam D., Huber, Victor C., Wang, Dan, Li, Feng
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592206/
https://ncbi.nlm.nih.gov/pubmed/32847862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00945-20
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