Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency

Creatine Transporter Deficiency (CTD) is an inborn error of metabolism presenting with intellectual disability, behavioral disturbances and epilepsy. There is currently no cure for this disorder. Here, we employed novel biomarkers for monitoring brain function, together with well-established behavio...

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Vydáno v:Sci Rep
Hlavní autoři: Cacciante, Francesco, Gennaro, Mariangela, Sagona, Giulia, Mazziotti, Raffaele, Lupori, Leonardo, Cerri, Elisa, Putignano, Elena, Butt, Mark, Do, Minh-Ha T., McKew, John C., Alessandrì, Maria Grazia, Battini, Roberta, Cioni, Giovanni, Pizzorusso, Tommaso, Baroncelli, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591530/
https://ncbi.nlm.nih.gov/pubmed/33110151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75436-4
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