A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice

Dilated cardiomyopathy (DCM) is a fatal heart disease characterized by left ventricular dilatation and cardiac dysfunction. Recent genetic studies on DCM have identified causative mutations in over 60 genes, including RBM20, which encodes a regulator of heart-specific splicing. DCM patients with RBM...

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Vydáno v:Sci Rep
Hlavní autoři: Ihara, Kensuke, Sasano, Tetsuo, Hiraoka, Yuichi, Togo-Ohno, Marina, Soejima, Yurie, Sawabe, Motoji, Tsuchiya, Megumi, Ogawa, Hidesato, Furukawa, Tetsushi, Kuroyanagi, Hidehito
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591520/
https://ncbi.nlm.nih.gov/pubmed/33110103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74800-8
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