Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling

ILC2s are present in adipose tissue and play a critical role in regulating adipose thermogenesis. However, the mechanisms underlying the activation of adipose-resident ILC2s remain poorly defined. Here, we show that IL-33, a potent ILC2 activator, stimulates phosphorylation of AMPK at Thr(172) via T...

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Published in:J Exp Med
Main Authors: Wang, Lu, Luo, Yan, Luo, Liping, Wu, Dandan, Ding, Xiaofeng, Zheng, Handong, Wu, Haisha, Liu, Bilian, Yang, Xin, Silva, Floyd, Wang, Chunqing, Zhang, Xing, Zheng, Xianyun, Chen, Jindong, Brigman, Jonathan, Mandell, Michael, Zhou, Zhiguang, Liu, Feng, Yang, Xuexian O., Liu, Meilian
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590510/
https://ncbi.nlm.nih.gov/pubmed/33104171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191054
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