Postnatal development of mice with combined genetic depletions of lamin A/C, emerin and lamina-associated polypeptide 1

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7–8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. We generated mice wi...

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Udgivet i:Hum Mol Genet
Main Authors: Wang, Yuexia, Shin, Ji-Yeon, Nakanishi, Koki, Homma, Shunichi, Kim, Grace J, Tanji, Kurenai, Joseph, Leroy C, Morrow, John P, Stewart, Colin L, Dauer, Willian T, Worman, Howard J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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General Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590221/
https://ncbi.nlm.nih.gov/pubmed/31009944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz082
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