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Celastrol Dilates and Counteracts Ethanol-Induced Constriction of Cerebral Arteries

The increasing recognition of the role played by cerebral artery dysfunction in brain disorders has fueled the search for new cerebrovascular dilators. Celastrol, a natural triterpene undergoing clinical trials for treating obesity, exerts neuroprotection, which was linked to its antioxidant/anti-in...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: North, Kelsey, Slayden, Alexandria, Mysiewicz, Steven, Bukiya, Anna, Dopico, Alex
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589950/
https://ncbi.nlm.nih.gov/pubmed/32862144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000152
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