Deuterium kinetic isotope effect studies of a potential in vivo metabolic trapping agent for Monoamine Oxidase-B

Visualizing the in vivo activity of monoamine oxidase B (MAO-B) is a valuable tool in the ongoing investigation into astrogliosis in neurodegeneration. Existing strategies for imaging changes in MAO enzyme expression or activity have utilized the irreversible suicide inhibitors or high-affinity reve...

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Udgivet i:ACS Chem Neurosci
Main Authors: Drake, Lindsey R., Brooks, Allen F., Mufarreh, Anthony J., Pham, Jonathan M., Koeppe, Robert A., Shao, Xia, Scott, Peter J.H., Kilbourn, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589526/
https://ncbi.nlm.nih.gov/pubmed/30074755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00219
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