T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which dysregulated Nod2 causes uveitis remain unknown. H...

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Vydáno v:Nat Commun
Hlavní autoři: Napier, Ruth J., Lee, Ellen J., Davey, Michael P., Vance, Emily E., Furtado, João M., Snow, Paige E., Samson, Kimberly A., Lashley, Sydney J., Brown, Brieanna R., Horai, Reiko, Mattapallil, Mary J., Xu, Biying, Callegan, Michelle C., Uebelhoer, Luke S., Lancioni, Christina L., Vehe, Richard K., Binstadt, Bryce A., Smith, Justine R., Caspi, Rachel R., Rosenzweig, Holly L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589501/
https://ncbi.nlm.nih.gov/pubmed/33106495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18961-0
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