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Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues

OrbiSIMS is a recently developed instrument for label‐free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo‐OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo‐OrbiSIMS boosts ioni...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Newell, Clare L., Vorng, Jean‐Luc, MacRae, James I., Gilmore, Ian S., Gould, Alex P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589292/
https://ncbi.nlm.nih.gov/pubmed/32603009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006881
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