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Spiropyran Meets Guanine Quadruplexes: Isomerization Mechanism and DNA Binding Modes of Quinolizidine‐Substituted Spiropyran Probes

The recent delivery of a fluorescent quinolizidine‐substituted spiropyran, which is able to switch in vivo and bind to guanine quadruplexes (G4) at physiological pH values, urged us to elucidate its molecular switching and binding mechanism. Combining multiscale dynamical studies and accurate quantu...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Avagliano, Davide, Sánchez‐Murcia, Pedro A., González, Leticia
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589282/
https://ncbi.nlm.nih.gov/pubmed/32368812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001586
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