Activation of the VEGF-A/ERK/PLA2 Axis Mediates Early Retinal Endothelial Cell Damage Induced by High Glucose: New Insight from an In Vitro Model of Diabetic Retinopathy

Early blood retinal barrier (BRB) dysfunction induced by hyperglycemia was related to increased pro-inflammatory activity of phospholipase A2 (PLA2) and the upregulation of vascular endothelial growth factor A (VEGF-A). Here, we tested the role of VEGF-A in high glucose (HG)-induced damage of human...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Giurdanella, Giovanni, Lupo, Gabriella, Gennuso, Florinda, Conti, Federica, Furno, Debora Lo, Mannino, Giuliana, Anfuso, Carmelina Daniela, Drago, Filippo, Salomone, Salvatore, Bucolo, Claudio
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589177/
https://ncbi.nlm.nih.gov/pubmed/33065984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207528
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