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Using a Human Papillomavirus Model to Study DNA Replication and Repair of Wild Type and Damaged DNA Templates in Mammalian Cells

Human papillomaviruses have 8kbp DNA episomal genomes that replicate autonomously from host DNA. During initial infection, the virus increases its copy number to 20–50 copies per cell, causing torsional stress on the replicating DNA. This activates the DNA damage response (DDR) and HPV replicates it...

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Das, Dipon, Bristol, Molly L., Pichierri, Pietro, Morgan, Iain M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589113/
https://ncbi.nlm.nih.gov/pubmed/33066318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207564
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