Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development

Hypoxia and inflammation are key factors for colorectal cancer tumorigenesis. The colonic epithelium belongs to the tissues with the lowest partial pressure of oxygen in the body, and chronic inflammation is associated with an increased chance to develop colon cancer. How the colonic epithelium resp...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Glaus Garzon, Jesus F., Pastrello, Chiara, Jurisica, Igor, Hottiger, Michael O., Wenger, Roland H., Borsig, Lubor
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588814/
https://ncbi.nlm.nih.gov/pubmed/33142239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.10.006
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