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Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites

SARS-CoV-2 ORF3a is believed to form ion channels, which may be involved in the modulation of virus release, and has been implicated in various cellular processes like the up-regulation of fibrinogen expression in lung epithelial cells, downregulation of type 1 interferon receptor, caspase-dependent...

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Publicat a:bioRxiv
Autors principals: Marquez-Miranda, Valeria, Rojas, Maximiliano, Duarte, Yorley, Diaz-Franulic, Ignacio, Holmgren, Miguel, Cachau, Raul E., Gonzalez-Nilo, Fernando D.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587776/
https://ncbi.nlm.nih.gov/pubmed/33106803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.22.349522
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