Novel canine isocitrate dehydrogenase 1 mutation Y208C attenuates dimerization ability

Isocitrate dehydrogenase 1 (IDH1) mutations are common in gliomas, acute myeloid leukemia, and chondrosarcoma. The mutation ‘hotspot’ is a single arginine residue, R132. The R132H mutant of IDH1 produces the 2-hydroxyglutarate (2-HG) carcinogen from α-ketoglutarate (α-KG). The reduction of α-KG indu...

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Published in:Oncol Lett
Main Authors: Kawakami, Shota, Michishita, Masaki, Sakaue, Motoharu, Morimatsu, Masami, Uemura, Mitsuki, Kashiwagi, Nobuaki, Maeda, Marika, Machida, Yukino, Azakami, Daigo, Egusa, Ai S., Onozawa, Eri, Ishioka, Katsumi, Watanabe, Masami, Tanaka, Yoshikazu, Omi, Toshinori, Ochiai, Kazuhiko
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586285/
https://ncbi.nlm.nih.gov/pubmed/33123262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.12214
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