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An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase

VCP/p97, an enzyme critical to proteostasis, is regulated through interactions with protein adaptors targeting it to specific cellular tasks. One such adaptor, p47, forms a complex with p97 to direct lipid membrane remodeling. Here, we use NMR and other biophysical methods to study the structural dy...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Conicella, Alexander E., Huang, Rui, Ripstein, Zev A., Nguyen, Ai, Wang, Eric, Löhr, Thomas, Schuck, Peter, Vendruscolo, Michele, Rubinstein, John L., Kay, Lewis E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585011/
https://ncbi.nlm.nih.gov/pubmed/33028677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013920117
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