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Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium

Nrf2 is a master regulator of antioxidant cellular defence, and agents activating the Nrf2 pathway have been tested in various diseases. However, unexpected side effects of cardiovascular nature reported for bardoxolone methyl in patients with type 2 diabetes mellitus and stage 4 chronic kidney dise...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Szczesny-Malysiak, Ewa, Stojak, Marta, Campagna, Roberto, Grosicki, Marek, Jamrozik, Marek, Kaczara, Patrycja, Chlopicki, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584962/
https://ncbi.nlm.nih.gov/pubmed/33123312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/4678252
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