Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling

Wnt signaling plays a critical role in production and differentiation of neurons and undergoes a progressive reduction during cortical development. However, how Wnt signaling is regulated is not well understood. Here we provide evidence for an indispensable role of neddylation, a ubiquitylation-like...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Lei, Jing, Hongyang, Li, Haiwen, Chen, Wenbing, Luo, Bin, Zhang, Hongsheng, Dong, Zhaoqi, Li, Lei, Su, Huabo, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584916/
https://ncbi.nlm.nih.gov/pubmed/33020269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005395117
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