Protective Effects of Simvastatin on Endotoxin-Induced Acute Kidney Injury through Activation of Tubular Epithelial Cells’ Survival and Hindering Cytochrome C-Mediated Apoptosis

Increasing evidence suggests that apoptosis of tubular cells and renal inflammation mainly determine the outcome of sepsis-associated acute kidney injury (AKI). The study aim was to investigate the molecular mechanism involved in the renoprotective effects of simvastatin in endotoxin (lipopolysaccha...

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Pubblicato in:Int J Mol Sci
Autori principali: Nežić, Lana, Škrbić, Ranko, Amidžić, Ljiljana, Gajanin, Radoslav, Milovanović, Zoran, Nepovimova, Eugenie, Kuča, Kamil, Jaćević, Vesna
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583796/
https://ncbi.nlm.nih.gov/pubmed/33008033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197236
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