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Elucidating the unusual reaction kinetics of D-glucuronyl C5-epimerase

The chemoenzymatic synthesis of heparin, through a multienzyme process, represents a critical challenge in providing a safe and effective substitute for this animal-sourced anticoagulant drug. D-glucuronyl C5-epimerase (C5-epi) is an enzyme acting on a heparin precursor, N-sulfoheparosan, catalyzing...

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Publicado en:Glycobiology
Main Authors: Vaidyanathan, Deepika, Paskaleva, Elena, Vargason, Troy, Ke, Xia, McCallum, Scott A, Linhardt, Robert J, Dordick, Jonathan S
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581656/
https://ncbi.nlm.nih.gov/pubmed/32304324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwaa035
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