Genetically Encoded Quinone Methides Enabling Rapid, Site-specific, and Photo-controlled Protein Modification with Amine Reagents

Site-specific modification of proteins with functional molecules provides powerful tools for researching and engineering proteins. Here we report a new chemical conjugation method which photocages highly reactive but chemically selective moieties, enabling the use of protein-inert amines for selecti...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Liu, Jun, Cheng, Rujin, Van Eps, Ned, Wang, Nanxi, Morizumi, Takefumi, Ou, Wei-Lin, Klauser, Paul C., Rozovsky, Sharon, Ernst, Oliver P., Wang, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581489/
https://ncbi.nlm.nih.gov/pubmed/32915556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06820
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