Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof-of-concept study

Therapeutically intervening the function of RNA in vivo remains a big challenge. We here developed an exosome-based strategy to deliver engineered RNA-binding protein for the purpose of recruiting specific RNA to the lysosomes for degradation. As a proof-of-principle study, RNA-binding protein HuR w...

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Bibliographische Detailangaben
Veröffentlicht in:J Extracell Vesicles
Hauptverfasser: Li, Zhelong, Zhou, Xueying, Gao, Xiaotong, Bai, Danna, Dong, Yan, Sun, Wenqi, Zhao, Lianbi, Wei, Mengying, Yang, Xuekang, Yang, Guodong, Yuan, Lijun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580726/
https://ncbi.nlm.nih.gov/pubmed/33133429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2020.1816710
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