Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules

Doxorubicin cardiotoxicity is frequently reported in patients undergoing chemotherapy. The present study investigates whether cardiomyopathy induced by doxorubicin can be improved by the natural flavone acacetin in a mouse model and uncovers the potential molecular mechanism using cultured rat cardi...

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Vydáno v:J Cell Mol Med
Hlavní autoři: Wu, Wei‐Yin, Cui, Yu‐Kai, Hong, Yi‐Xiang, Li, Yun‐Da, Wu, Yao, Li, Gang, Li, Gui‐Rong, Wang, Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579684/
https://ncbi.nlm.nih.gov/pubmed/32918384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15859
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