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Newly established gastrointestinal cancer cell lines retain the genomic and immunophenotypic landscape of their parental cancers

Human cancer cell lines are frequently used as model systems to study molecular mechanisms and genetic changes in cancer. However, the model is repeatedly criticized for its lack of proximity to original patient tumors. Therefore, understanding to what extent cell lines cultured under artificial con...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Hirsch, Daniela, Seyfried, Steffen, Staib, Tobias, Fiedler, David, Sauer, Christian, Ried, Thomas, Witt, Stephanie, Rueckert, Felix, Gaiser, Timo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578805/
https://ncbi.nlm.nih.gov/pubmed/33087752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74797-0
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