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CHIP mutations affect the heat shock response differently in human fibroblasts and iPSC-derived neurons
C-terminus of HSC70-interacting protein (CHIP) encoded by the gene STUB1 is a co-chaperone and E3 ligase that acts as a key regulator of cellular protein homeostasis. Mutations in STUB1 cause autosomal recessive spinocerebellar ataxia type 16 (SCAR16) with widespread neurodegeneration manifesting as...
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| Publié dans: | Dis Model Mech |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists Ltd
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7578354/ https://ncbi.nlm.nih.gov/pubmed/33097556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.045096 |
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