Anti-cancer strategy targeting the energy metabolism of tumor cells surviving a low-nutrient acidic microenvironment

OBJECTIVE: Tumor cells experience hypoxia, acidosis, and hypoglycemia. Metabolic adaptation to glucose shortage is essential to maintain tumor cells’ survival because of their high glucose requirement. This study evaluated the hypothesis that acidosis might promote tumor survival during glucose shor...

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Vydáno v:Mol Metab
Hlavní autoři: Maeda, Yuki, Kikuchi, Ryota, Kawagoe, Junichiro, Tsuji, Takao, Koyama, Nobuyuki, Yamaguchi, Kazuhiro, Nakamura, Hiroyuki, Aoshiba, Kazutetsu
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578269/
https://ncbi.nlm.nih.gov/pubmed/33007425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101093
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