Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death

Early rejection is a critical issue to be overcome to achieve successful islet transplantation. NLRP3 inflammasome is a protein complex that mediates the maturation of pro-interleukin (IL)-1β and pro-IL-18 to IL-1β and IL-18, respectively, which induce cellular death. Here, we investigated the impac...

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Publicado no:Sci Rep
Main Authors: Matsuoka, Taisuke, Yoshimatsu, Gumpei, Sakata, Naoaki, Kawakami, Ryo, Tanaka, Tomoko, Yamada, Teppei, Yoshida, Yoichiro, Hasegawa, Suguru, Kodama, Shohta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578017/
https://ncbi.nlm.nih.gov/pubmed/33087823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74786-3
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