Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids

Multidimensional TOCSY and NOESY are central experiments in chemical and biophysical NMR. Limited efficiencies are an intrinsic downside of these methods, particularly when targeting labile sites. This study demonstrates that the decoherence imparted on these protons through solvent exchanges can, w...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Novakovic, Mihajlo, Kupče, Ēriks, Oxenfarth, Andreas, Battistel, Marcos D., Freedberg, Darón I., Schwalbe, Harald, Frydman, Lucio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577996/
https://ncbi.nlm.nih.gov/pubmed/33087707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19108-x
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