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Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids

Multidimensional TOCSY and NOESY are central experiments in chemical and biophysical NMR. Limited efficiencies are an intrinsic downside of these methods, particularly when targeting labile sites. This study demonstrates that the decoherence imparted on these protons through solvent exchanges can, w...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Novakovic, Mihajlo, Kupče, Ēriks, Oxenfarth, Andreas, Battistel, Marcos D., Freedberg, Darón I., Schwalbe, Harald, Frydman, Lucio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577996/
https://ncbi.nlm.nih.gov/pubmed/33087707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19108-x
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