Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction

Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an understanding of coronavirus disease 2019 (COVID-19) pathogenesis. Here, we report a feeder-free, scalable, chemically defin...

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Publicado en:Cell Stem Cell
Main Authors: Katsura, Hiroaki, Sontake, Vishwaraj, Tata, Aleksandra, Kobayashi, Yoshihiko, Edwards, Caitlin E., Heaton, Brook E., Konkimalla, Arvind, Asakura, Takanori, Mikami, Yu, Fritch, Ethan J., Lee, Patty J., Heaton, Nicholas S., Boucher, Richard C., Randell, Scott H., Baric, Ralph S., Tata, Purushothama Rao
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Inc. 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577733/
https://ncbi.nlm.nih.gov/pubmed/33128895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.10.005
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