The cytotoxic molecule granulysin is capable of inducing either chemotaxis or fugetaxis in dendritic cells depending on maturation: a role for Vδ2(+) γδ T cells in the modulation of immune response to tumour?

Release of granulysin by γδ T cells contributes to tumour cell killing. A cytolytic 9000 MW isoform of granulysin kills tumour cells directly, whereas a 15 000 MW precursor has been hypothesized to cause both the maturation and migration of dendritic cell (DC) populations. Recruiting DC to a tumour...

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Publicado en:Immunology
Autores principales: Sparrow, Emma L., Fowler, Daniel W., Fenn, Joe, Caron, Jonathan, Copier, John, Dalgleish, Angus G., Bodman‐Smith, Mark D.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576882/
https://ncbi.nlm.nih.gov/pubmed/32794189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13248
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