Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion

Testosterone (T) affects β-cell function in men and women. T is a prohormone that undergoes intracrine conversion in target tissues to the potent androgen dihydrotestosterone (DHT) via the enzyme 5α-reductase (5α-R) or to the active estrogen 17β-estradiol (E2) via the aromatase enzyme. Using male an...

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Publicat a:Diabetes
Autors principals: Xu, Weiwei, Schiffer, Lina, Qadir, M.M. Fahd, Zhang, Yanqing, Hawley, James, Mota De Sa, Paula, Keevil, Brian G., Wu, Hongju, Arlt, Wiebke, Mauvais-Jarvis, Franck
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2020
Matèries:
Islet Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576567/
https://ncbi.nlm.nih.gov/pubmed/32855171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0228
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