Identification of a Distal Locus Enhancer Element That Controls Cell Type–Specific TNF and LTA Gene Expression in Human T Cells

The human TNF/LT locus genes TNF, LTA, and LTB are expressed in a cell type–specific manner. In this study, we show that a highly conserved NFAT binding site within the distal noncoding element hHS-8 coordinately controls TNF and LTA gene expression in human T cells. Upon activation of primary human...

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Bibliographic Details
Published in:J Immunol
Main Authors: Jasenosky, Luke D., Nambu, Aya, Tsytsykova, Alla V., Ranjbar, Shahin, Haridas, Viraga, Kruidenier, Laurens, Tough, David F., Goldfeld, Anne E.
Format: Artigo
Language:Inglês
Published: AAI 2020
Subjects:
Innate Immunity and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576113/
https://ncbi.nlm.nih.gov/pubmed/32978279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901311
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