Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans

Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin...

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Publicado en:Cell Rep Med
Main Authors: Hornsby, Amanda K.E., Buntwal, Luke, Carisi, Maria Carla, Santos, Vanessa V., Johnston, Fionnuala, Roberts, Luke D., Sassi, Martina, Mequinion, Mathieu, Stark, Romana, Reichenbach, Alex, Lockie, Sarah H., Siervo, Mario, Howell, Owain, Morgan, Alwena H., Wells, Timothy, Andrews, Zane B., Burn, David J., Davies, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575905/
https://ncbi.nlm.nih.gov/pubmed/33103129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100120
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