Modeling Klinefelter Syndrome Using Induced Pluripotent Stem Cells Reveals Impaired Germ Cell Differentiation

Klinefelter syndrome (KS), with an incidence between 1/600 and 1/1,000, is the main genetic cause of male infertility. Due to the lack of an accurate study model, the detailed pathogenic mechanisms by which this X chromosome aneuploidy leads to KS features remain unknown. Here, we report the generat...

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Publicat a:Front Cell Dev Biol
Autors principals: Botman, Olivier, Hibaoui, Youssef, Giudice, Maria G., Ambroise, Jérôme, Creppe, Catherine, Feki, Anis, Wyns, Christine
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575714/
https://ncbi.nlm.nih.gov/pubmed/33117798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.567454
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