Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR

Myelin Protein Zero (MPZ/P0) is the most abundant glycoprotein of peripheral nerve myelin. P0 is synthesized by myelinating Schwann cells, processed in the endoplasmic reticulum (ER) and delivered to myelin via the secretory pathway. The mutant P0S63del (deletion of serine 63 in the extracellular do...

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Vydáno v:J Neurosci
Hlavní autoři: Scapin, Cristina, Ferri, Cinzia, Pettinato, Emanuela, Bianchi, Francesca, Del Carro, Ubaldo, Feltri, M. Laura, Kaufman, Randal J., Wrabetz, Lawrence, D'Antonio, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574653/
https://ncbi.nlm.nih.gov/pubmed/32973043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0957-20.2020
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