Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR

Myelin Protein Zero (MPZ/P0) is the most abundant glycoprotein of peripheral nerve myelin. P0 is synthesized by myelinating Schwann cells, processed in the endoplasmic reticulum (ER) and delivered to myelin via the secretory pathway. The mutant P0S63del (deletion of serine 63 in the extracellular do...

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Publicat a:J Neurosci
Autors principals: Scapin, Cristina, Ferri, Cinzia, Pettinato, Emanuela, Bianchi, Francesca, Del Carro, Ubaldo, Feltri, M. Laura, Kaufman, Randal J., Wrabetz, Lawrence, D'Antonio, Maurizio
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574653/
https://ncbi.nlm.nih.gov/pubmed/32973043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0957-20.2020
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