T-Cell Therapeutics Targeting Human Parainfluenza Virus 3 Are Broadly Epitope Specific and Are Cross Reactive With Human Parainfluenza Virus 1

Human Parainfluenza Virus-3 (HPIV3) causes severe respiratory illness in immunocompromised patients and lacks approved anti-viral therapies. A phase I study of adoptively transferred virus-specific T-cells (VSTs) targeting HPIV3 following bone marrow transplantation is underway (NCT03180216). We sou...

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Udgivet i:Front Immunol
Main Authors: Harris, Katherine M., Horn, Sarah E., Grant, Melanie L., Lang, Haili, Sani, Gelina, Jensen-Wachspress, Mariah A., Kankate, Vaishnavi V., Datar, Anushree, Lazarski, Christopher A., Bollard, Catherine M., Keller, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573487/
https://ncbi.nlm.nih.gov/pubmed/33123159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.575977
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