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Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks

In a healthy person, the kidney filters nearly 200 g of glucose per day, almost all of which is reabsorbed. The primary transporter responsible for renal glucose reabsorption is sodium-glucose cotransporter-2 (SGLT2). Based on the impact of SGLT2 to prevent renal glucose wasting, SGLT2 inhibitors ha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Perry, Rachel J., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573269/
https://ncbi.nlm.nih.gov/pubmed/32796035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.REV120.008387
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