Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Although most bone fractures typically heal without complications, a small proportion of patients (≤10%) experience delayed healing or potential progression to non-union. Interleukin-1 (IL-1β) plays a crucial role in fracture healing as an early driver of inflammation. However, the effects of IL-1β...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Lackington, William A., Gomez-Sierra, Maria Antonia, González-Vázquez, Arlyng, O’Brien, Fergal J., Stoddart, Martin J., Thompson, Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573213/
https://ncbi.nlm.nih.gov/pubmed/33123517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.582012
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